Endocrine Abstracts

Introduction: Thyroid nodules may be detected in up to 67% of the adult population and constitute big diagnostic challenge. Presurgical differentiation of follicular lesions between follicular adenoma (FA) and follicular thyroid carcinoma (FTC) is particularly difficult. Commercially available gene panels cover only a few, selected mutations to help in discrimination between FA and FTC. The aim of this study was to comprehensively assess the genetic background of thyroid folli...

Introduction: The number of thyroid cancer diagnosis has increased worldwide. However, its diagnosis, particularly in a case of follicular cancer (FTC), may be challenging. New markers of malignancy are intensively searched for.Case description: A 29-year-old female was referred for subtotal thyroidectomy in 2006 due to a nodule in the right lobe. The histopathological examination revealed follicular adenoma (FA). During endocrinological follow-up, in 20...

Introduction: Combined pituitary hormone deficiency (CPHD) results in deficit of growth hormone and coexisting failure of synthesis or excretion at least another pituitary hormone. Transcription factors controlling expression of genes required for pituitary organogenesis are orchestrating entire development process and certain cell lineages differentiation, contributing therefore significantly to CPHD pathogenesis with childhood onset.Aims: The purpose o...